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Monyer group

Principal investigator:
Abt. Klinische Neurobiologie des Universitätsklinikums und des DKFZ
DKFZ / A230
Im Neuenheimer Feld 280
69120 Heidelberg

0049-6221-42-3100 / 42-3101

General research interests and goals:

Our group investigates the role of glutamate receptors and gap junctions for the function of hippocampal and entorhinal network activity. Our particular interest pertains to the consequences of interneuron specific deletions of these molecules for hippocampal and entorhinal oscillatory activity, place and grid cells and mouse behavior. To elucidate these questions we use the following methodological approaches: - Generation of cell type- and region-specific knockouts
- In vitro and in vivo electrophysiology with analysis of local-field potentials and single-unit recordings (place and grid cells) - Behavioral analyses of transgenic mice including testing of hippocampal dependent behavior such as spatial working and reference memory


B1 B2

Current group members:

PostDocs: Oleg Senkov / Dr. Yasuhito Watanabe
PhD students: Christina Buetfering
Associates: Sarah Melzer / Kevin Allen / Antonio Caputi / Magdalena Michael

Key publications:

Leitner FC, Melzer S, Lütcke H, Pinna R, Seeburg PH, Helmchen F, Monyer H (2016) Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex Nat. Neurosci. 19(7): 935-944 .
Fuchs EC, Neitz A, Pinna R, Melzer S, Caputi A, Monyer H (2016) Local and Distant Input Controlling Excitation in Layer II of the Medial Entorhinal Cortex Neuron 89: 194-208 .
Buetfering C, Allen K, Monyer H (2014) Parvalbumin interneurons provide grid cell-driven recurrent inhibition in the medial entorhinal cortex Nat. Neurosci. 17: 710-718 .
Allen K, Gil M, Resnik E, Toader O, Seeburg P, Monyer H (2014) Impaired path integration and grid cell spatial periodicity in mice lacking GluA1-containing AMPA receptors J. Neurosci. 34: 6245-6259 .
Melzer S, Michael M, Caputi A, Eliava M, Fuchs EC, Whittington MA, Monyer H (2012) Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex Science 335: 1506-1510 .